Comparison of potentiality to induce graft-versus-host reaction with small bowel, pancreas/spleen, and liver transplantation in the rat.

@article{Kobayashi1993ComparisonOP,
  title={Comparison of potentiality to induce graft-versus-host reaction with small bowel, pancreas/spleen, and liver transplantation in the rat.},
  author={Eiji Kobayashi and Naoshi Kamada and Shin Enosawa and Naomi Toyama and Luc Delriviere and Shigeru Goto and Yang Il Kim and Michio Miyata},
  journal={Clinical and experimental immunology},
  year={1993},
  volume={92 3},
  pages={527-31}
}
Although small bowel transplantation (SBT), or pancreas-spleen transplantation (PST) often lead to lethal graft-versus-host reaction (GVHR) in experimental animals, fatal GVHR is rare after clinical liver transplantation. This study describes a modified model of SBT and PST in the rat using cuff techniques applied to the renal artery and vein of the recipient. The ability of LEW (RT1(1)) or BN (RT1n) lymphocytes accompanying intestinal, splenic, or hepatic grafts to induce lethal GVHR in (LEW x… CONTINUE READING