Comparison of population-averaged and subject-specific approaches for analyzing repeated binary outcomes.

  title={Comparison of population-averaged and subject-specific approaches for analyzing repeated binary outcomes.},
  author={Frank B Hu and J. Goldberg and Donald Hedeker and Brian R. Flay and Mary Ann Pentz},
  journal={American journal of epidemiology},
  volume={147 7},
Several approaches have been proposed to model binary outcomes that arise from longitudinal studies. Most of the approaches can be grouped into two classes: the population-averaged and subject-specific approaches. The generalized estimating equations (GEE) method is commonly used to estimate population-averaged effects, while random-effects logistic models can be used to estimate subject-specific effects. However, it is not clear to many epidemiologists how these two methods relate to one… CONTINUE READING

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