Comparison of plasma and saliva levels of metoprolol and oxprenolol.

@article{Dawes1978ComparisonOP,
  title={Comparison of plasma and saliva levels of metoprolol and oxprenolol.},
  author={C P Dawes and Martin J. Kendall and Vivian A. John},
  journal={British journal of clinical pharmacology},
  year={1978},
  volume={5 3},
  pages={217-21}
}
1 Plasma and saliva levels of metoprolol and oxprenolol have been compared in two groups of healthy volunteers. 2 Mean salivary oxprenolol levels were lower than, but closely related to the corresponding plasma levels (r=0.93), the mean ratio of saliva:plasma concentration being 0.42. 3 Mean salivary metoprolol concentrations were considerably greater thatn the corresponding plasma levels and the relationship between the concentrations in the two fluids was less clear. 4 The evidence presented… CONTINUE READING