Comparison of plasma and interstitial fluid concentrations of doxycycline and meropenem following constant rate intravenous infusion in dogs.

@article{Bidgood2003ComparisonOP,
  title={Comparison of plasma and interstitial fluid concentrations of doxycycline and meropenem following constant rate intravenous infusion in dogs.},
  author={T L Bidgood and Mark G Papich},
  journal={American journal of veterinary research},
  year={2003},
  volume={64 8},
  pages={
          1040-6
        }
}
OBJECTIVE To compare plasma (total and unbound) and interstitial fluid (ISF) concentrations of doxycycline and meropenem in dogs following constant rate IV infusion of each drug. ANIMAL 6 adult Beagles. PROCEDURE Dogs were given a loading dose of doxycycline and meropenem followed by a constant rate IV infusion of each drug to maintain an 8-hour steady state concentration. Interstitial fluid was collected with an ultrafiltration device. Plasma and ISF were analyzed by high performance… CONTINUE READING

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