Comparison of phenotypic and genotypic methods for detection of diphtheria toxin among isolates of pathogenic corynebacteria.

@article{Efstratiou1998ComparisonOP,
  title={Comparison of phenotypic and genotypic methods for detection of diphtheria toxin among isolates of pathogenic corynebacteria.},
  author={Androulla Efstratiou and Kathryn H. Engler and C S Dawes and Dorothea Sesardic},
  journal={Journal of clinical microbiology},
  year={1998},
  volume={36 11},
  pages={3173-7}
}
We have compared molecular, immunochemical, and cytotoxic assays for the detection of diphtheria toxin from 55 isolates of Corynebacterium diphtheriae and Corynebacterium ulcerans originally isolated in five different countries. The suitabilities and accuracies of these assays for the laboratory diagnosis of diphtheria were compared and evaluated against the "gold standard" in vivo methods. The in vivo and Vero cell cytotoxicity assays were accurate in their abilities to detect diphtheria toxin… CONTINUE READING

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Manual for the laboratory diagnosis of diphtheria

  • A. Efstratiou, P.A.C. Maple
  • Expanded Programme on Immunization in the…
  • 1994
Highly Influential
5 Excerpts

Epidemic diphtheria in the Newly Independent States and the Baltic countries. Working Paper CMDS01. Expanded Programme on Immunization, World Health Organization Regional Office for Europe

  • S. Dittmann
  • Seventh Meeting of National Programme Managers
  • 1997
1 Excerpt

Microbiology and epidemiology of diphtheria

  • A. Efstratiou, R. C. George
  • Rev. Med. Microbiol
  • 1996
2 Excerpts

Incidence of diphtheria and other infections caused by Corynebacterium diphtheriae and C. ulcerans in England and Wales: 1986–1993

  • J. White, A. Efstratiou
  • Proceedings of the First International Meeting of…
  • 1995

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