Comparison of pharmacokinetics between loxoprofen and its derivative with lower ulcerogenic activity, fluoro-loxoprofen.

@article{Yamakawa2013ComparisonOP,
  title={Comparison of pharmacokinetics between loxoprofen and its derivative with lower ulcerogenic activity, fluoro-loxoprofen.},
  author={Naoki Yamakawa and Shintaro Suemasu and Hiroshi Watanabe and Kayoko Tahara and Ken-ichiro Tanaka and Yoshinari Okamoto and Masami Ohtsuka and Toru Maruyama and Tohru Mizushima},
  journal={Drug metabolism and pharmacokinetics},
  year={2013},
  volume={28 2},
  pages={
          118-24
        }
}
  We recently reported that, compared to loxoprofen (LOX, an non-steroidal anti-inflammatory drug), the LOX derivative fluoro-loxoprofen (F-LOX) is less ulcerogenic but has similar anti-inflammatory activity. Our previous in vitro studies suggested that both LOX and F-LOX are pro-drugs, the active metabolites of which are their trans-alcohol forms. In this study, we compared the pharmacokinetics of F-LOX and LOX in rats. Overall, the pharmacokinetic characteristics of F-LOX, including the… Expand
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