Comparison of pharmacokinetics and pathology for low-dose tacrolimus once-daily and twice-daily in living kidney transplantation: prospective trial in once-daily versus twice-daily tacrolimus.

@article{Tsuchiya2013ComparisonOP,
  title={Comparison of pharmacokinetics and pathology for low-dose tacrolimus once-daily and twice-daily in living kidney transplantation: prospective trial in once-daily versus twice-daily tacrolimus.},
  author={Tomohiro Tsuchiya and Hideki Ishida and Tatsu Tanabe and Tomokazu Shimizu and Kazuho Honda and Kazuya Omoto and Kazunari Tanabe},
  journal={Transplantation},
  year={2013},
  volume={96 2},
  pages={
          198-204
        }
}
BACKGROUND A prolonged-release formulation of tacrolimus (Tacrolimus QD) was developed to allow once-daily dosing and to have similar safety and efficacy profiles to twice-daily tacrolimus (Tacrolimus BID). This study compared the pharmacokinetics (PK) and renal pathology by protocol biopsy in de novo living kidney transplant recipients treated with either low-dose Tacrolimus QD or Tacrolimus BID. METHODS Between November 2009 and January 2011, 102 consecutive adult patients were randomized… CONTINUE READING
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