Comparison of pharmacokinetic interactions and physiologically based pharmacokinetic modeling of PCB 153 and PCB 126 in nonpregnant mice, lactating mice, and suckling pups.

@article{Lee2002ComparisonOP,
  title={Comparison of pharmacokinetic interactions and physiologically based pharmacokinetic modeling of PCB 153 and PCB 126 in nonpregnant mice, lactating mice, and suckling pups.},
  author={Sun Ku Lee and Ying C. Ou and Raymond S. H. Yang},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2002},
  volume={65 1},
  pages={
          26-34
        }
}
  • Sun Ku Lee, Ying C. Ou, Raymond S. H. Yang
  • Published in
    Toxicological sciences : an…
    2002
  • Chemistry, Medicine
  • Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants that can induce neurological defects in infants and children via placental and lactational transfer. To investigate the lactational transfer of PCBs and compare pharmacokinetic interactions among nonpregnant, lactating mice and suckling pups, quantitative time-course measurements of PCB accumulation in tissues were performed. On postnatal day 1, nonpregnant and lactating C57BL/6 mice were exposed to PCB 153 (2,2',4,4',5… CONTINUE READING

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