Comparison of p16(INK4a) expression with p53 alterations in head and neck cancer by tissue microarray analysis.

@article{Karsai2007ComparisonOP,
  title={Comparison of p16(INK4a) expression with p53 alterations in head and neck cancer by tissue microarray analysis.},
  author={Syrus Karsai and U. Abel and Mariana Roesch-Ely and Annette Affolter and Christof Hofele and Sebastian Joos and Peter K. Plinkert and Franz X. Bosch},
  journal={The Journal of pathology},
  year={2007},
  volume={211 3},
  pages={
          314-22
        }
}
We investigated whether there is a relationship between loss of p16(INK4a) protein expression and p53 alterations in head and neck squamous cell carcinomas (HNSCCs). For this purpose, immunohistochemistry was performed on tissue microarrays of 664 tumours; this represents the largest HNSCC cohort studied for molecular biomarkers. Loss of p16(INK4a) protein expression was associated with aberrant p53 expression (negative or overexpressed) in the total cohort, and with TP53 mutations in 200… CONTINUE READING

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