Comparison of osteogenic potentials of human rat BMP4 and BMP6 gene therapy using [E1-] and [E1-,E2b-] adenoviral vectors

Abstract

Osteogenic potentials of some recombinant human bone morphogenetic protein (BMP) first-generation adenoviral vectors (ADhBMPs) are significantly limited in immunocompetent animals. It is unclear what role expression of viral proteins and foreign proteins transduced by adenoviral vectors play in the host immune response and in ectopic bone formation. In this… (More)

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@article{Li2006ComparisonOO, title={Comparison of osteogenic potentials of human rat BMP4 and BMP6 gene therapy using [E1-] and [E1-,E2b-] adenoviral vectors}, author={Hongwei Li and Jin Li and Debra D. Pittman and Andy Amalfitano and Gerald R. Hankins and Gregory A. Helm}, journal={International Journal of Medical Sciences}, year={2006}, volume={3}, pages={97 - 105} }