Comparison of oral artesunate and quinine plus tetracycline in acute uncomplicated falciparum malaria.

@article{Karbwang1994ComparisonOO,
  title={Comparison of oral artesunate and quinine plus tetracycline in acute uncomplicated falciparum malaria.},
  author={Juntra Karbwang and Kesara Na-Bangchang and A. Thanavibul and Danai Bunnag and Tan Chongsuphajaisiddhi and T Harinasuta},
  journal={Bulletin of the World Health Organization},
  year={1994},
  volume={72 2},
  pages={233-8}
}
In Thailand Plasmodium falciparum malaria is highly resistant to available antimalarials. Investigations on the efficacy of existing antimalarials and of alternative drugs are urgently needed. Artesunate has been shown to be effective against falciparum malaria, but is associated with a high recrudescence rate. We have carried out a comparative clinical trial of the standard regimen of quinine + tetracycline versus oral artesunate at a 700-mg total dose given over 5 days to patients with acute… CONTINUE READING