Comparison of oral and transdermal administration of rasagiline mesylate on human melanoma tumor growth in vivo

  title={Comparison of oral and transdermal administration of rasagiline mesylate on human melanoma tumor growth in vivo},
  author={Susan R. Meier-Davis and Kevin C. Dines and Fatima M Arjmand and R Hamlin and Betsy Huang and Jainye Wen and Chad C Christianson and Jutaro Shudo and Tetsuto Nagata},
  journal={Cutaneous and Ocular Toxicology},
  pages={312 - 317}
Background/Aims: Transdermal patch administration results in a locally high concentration of drug that induce local toxicity, including tumorogenicity. As a worst-case scenario for consequences of repeated application on neoplastic growth, the melanin-binding drug, rasagiline, was used in a transdermal formulation applied directly to a human-derived melanoma to determine the effects on tumor growth. Materials and Methods: Rasagiline mesylate was administered either orally or transdermally to… Expand
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