Comparison of one-step and two-step meta-analysis models using individual patient data.

@article{Mathew2010ComparisonOO,
  title={Comparison of one-step and two-step meta-analysis models using individual patient data.},
  author={Thomas Mathew and Kenneth Nordstr{\"o}m},
  journal={Biometrical journal. Biometrische Zeitschrift},
  year={2010},
  volume={52 2},
  pages={271-87}
}
The problem of combining information from separate trials is a key consideration when performing a meta-analysis or planning a multicentre trial. Although there is a considerable journal literature on meta-analysis based on individual patient data (IPD), i.e. a one-step IPD meta-analysis, versus analysis based on summary data, i.e. a two-step IPD meta-analysis, recent articles in the medical literature indicate that there is still confusion and uncertainty as to the validity of an analysis… CONTINUE READING

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Optimum Experimental Designs (A. C. Atkinson and A. N. Donev)

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