Comparison of omeprazole and cimetidine in reflux oesophagitis: symptomatic, endoscopic, and histological evaluations.

@article{Bate1990ComparisonOO,
  title={Comparison of omeprazole and cimetidine in reflux oesophagitis: symptomatic, endoscopic, and histological evaluations.},
  author={Cheryl Bate and P. W. Napoleon Keeling and Colm O'mor{\'a}in and Stephen P. Wilkinson and David N Foster and Richard A. Mountford and John Temperley and Richard F. Harvey and David G. Thompson and Michele E. Davis},
  journal={Gut},
  year={1990},
  volume={31 9},
  pages={968-72}
}
Symptomatic patients with endoscopically verified reflux oesophagitis were randomised to a double blind trial in which they received either omeprazole (20 mg once daily) or cimetidine (400 mg four times daily) for four, and if necessary, eight weeks. In an 'intention to treat' analysis, oesophagitis was found to have healed after four weeks in 77 of 137 (56%) in the omeprazole group and in 34 of 133 (26%) in the cimetidine group (p less than 0.001). By eight weeks these values were 71% and 35… CONTINUE READING
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Omeprazole dose response effect on 24 hour esophageal acid exposure in patients with symptomatic gastroesophageal reflux disease

  • MG Robinson, TJ Humphries, D McIntosh, ML Allen, AJ Gagliola, TE Broadstreet
  • Gastro - enterology
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Randomised , double blind comparison of omeprazole and cimetidine in the treatment of symptomatic gastric ulcer

  • CM Bate, SP Wilkinson, Bradby GVH
  • Gut
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