Comparison of observational and controlled clinical trials of diltiazem in the treatment of chronic anal fissure.

@article{Medhi2011ComparisonOO,
  title={Comparison of observational and controlled clinical trials of diltiazem in the treatment of chronic anal fissure.},
  author={Bikash Medhi and Ajay Prakash and Sujata Upadhyay and Deonis Xess and Thakur Deen Yadav and Lileswar Kaman},
  journal={The Indian journal of surgery},
  year={2011},
  volume={73 6},
  pages={427-31}
}
Diltiazem has been extensively studied in the treatment of chronic anal fissures, but efficacy in clinical practice is not fully established. The aim of the present study was to evaluate the safety and efficacy of topical application diltiazem in observational studies as well as in controlled clinical trials in the treatment of chronic anal fissures. A systematic literature search was carried out from 1966 to 31 December, 2007 on PubMed, Medline, Embase and Cochrane database, using the… CONTINUE READING

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