Comparison of nucleotide sequences in HeLa cell mRNA and hnRNA.


Nearest neighbour analysis of nucleotides in vertebrate DNA has revealed a marked deficiency in the frequency of occurrence of the sequence CpGp. By use of the fingerprinting technique of Sanger et al. (1965) to characterise the nucleotide sequences of HeLa cell hnRNA after T1 RNAase digestion, we have shown that this deficiency also occurs in hnRNA and… (More)

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