Comparison of noninvasive models of fibrosis in chronic hepatitis B

@article{Raftopoulos2011ComparisonON,
  title={Comparison of noninvasive models of fibrosis in chronic hepatitis B},
  author={Spiro C. Raftopoulos and Jacob George and Marc Bourlière and Enrico Rossi and W. Bastiaan de Boer and Gary P. Jeffrey and Max K. Bulsara and David John Speers and Gerry Macquillan and Helena L. Ching and Nickolas Kontorinis and Wendy S C Cheng and James P. Flexman and Soraya Fermoyle and Paul H. Rigby and L L Walsh and Duncan J. Mcleod and Leon A. Adams},
  journal={Hepatology International},
  year={2011},
  volume={6},
  pages={457-467}
}
Background and goalsLiver fibrosis influences treatment and surveillance strategies in chronic hepatitis B (CHB). This multicenter study aimed to examine the accuracy of serum fibrosis models in CHB patients including those with low alanine aminotransferase (ALT) levels and serially in those undergoing treatment.MethodWe examined noninvasive fibrosis models [Hepascore, Fibrotest, APRI, hepatitis e antigen (HBeAg)-positive and -negative models] in 179 CHB patients who underwent liver biopsy and… 

Prospective Validation of FibroTest in Comparison with Liver Stiffness for Predicting Liver Fibrosis in Asian Subjects with Chronic Hepatitis B

FT substantially reduces need for liver biopsy, especially when used in combination with LS, and provides good fibrosis prediction, with comparable outcomes to LS in Asian chronic hepatitis B patients.

Non-invasive assessment of liver fibrosis in patients with chronic hepatitis B

Transient elastography, FibroTest and API are the mostwidely validated non-invasive method for liverfibrosis assessment and a combined application of tran-sientElastography and biomarkers may be the preferredcourse of action.

Performance of Enhanced Liver Fibrosis test and comparison with transient elastography in the identification of liver fibrosis in patients with chronic hepatitis B infection

It is demonstrated that ELF has good performance in detection of liver fibrosis in patients with CHB, and when compared, TE performs better in Detection of severe fibrosis/cirrhosis.

Hepascore and hyaluronic acid as markers of fibrosis in liver disease of mixed aetiology

Although HA and Hepascore may be useful where the disease aetiology is known, particularly in established hepatitis C virus, the high cost of false positives and false negatives are such that neither a reliable enough to replace biopsy without substantial further characterization.

High biological variation of serum hyaluronic acid and Hepascore, a biochemical marker model for the prediction of liver fibrosis

When using non-fasting serum samples, hyaluronic acid and to a lesser extent, the Hepascore model display large within-individual variations in both health and chronic liver disease.

Comparison of diagnostic accuracy of aspartate aminotransferase to platelet ratio index and fibrosis‐4 index for detecting liver fibrosis in adult patients with chronic hepatitis B virus infection: A systemic review and meta‐analysis

The meta‐analysis suggests that APRI and FIB‐4 can identify hepatitis B‐related fibrosis with a moderate sensitivity and accuracy.

Transient Elastography is Superior to the FIB 4 Index, Aspartate Platelet Ratio Index, Aspartate Alanine Aminotransferase Ratio, Age Platelet Index and Fibrosis Index in Diagnosing Fibrosis in Chronic Hepatitis B Patients

Transient Elastography has excellent accuracy for F4 and F≥3 and can reduce the need for liver biopsies in the majority of chronic hepatitis B patients and was the most superior non-invasive measure for every stage of fibrosis when compared with FIB-4I, APRI, API, AAR and FI.

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