Comparison of nonhomologous end joining and homologous recombination in human cells.

Abstract

The two major pathways for repair of DNA double-strand breaks (DSBs) are homologous recombination (HR) and nonhomologous end joining (NHEJ). HR leads to accurate repair, while NHEJ is intrinsically mutagenic. To understand human somatic mutation it is essential to know the relationship between these pathways in human cells. Here we provide a comparison of… (More)
DOI: 10.1016/j.dnarep.2008.06.018

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