Comparison of new patients with Bence-Jones, IgG and IgA myeloma receiving sequential therapy: the need to regard these immunologic subtypes as separate disease entities with specific prognostic criteria

@article{Sirohi2001ComparisonON,
  title={Comparison of new patients with Bence-Jones, IgG and IgA myeloma receiving sequential therapy: the need to regard these immunologic subtypes as separate disease entities with specific prognostic criteria},
  author={Bhawna Sirohi and Ray L Powles and Samar Kulkarni and Claudius E. Rudin and Radovan M Saso and Rohit Lal and Seema B. Singhal and Jayesh Mehta and Clive Horton and Jennifer G. Treleaven},
  journal={Bone Marrow Transplantation},
  year={2001},
  volume={28},
  pages={29-37}
}
Of the 61 newly diagnosed patients with Bence-Jones (BJ) myeloma presenting to our centre between May 1986 and December 1997, 53 received sequential therapy (ST) comprising infusional chemotherapy (IC) followed by high-dose therapy and autotransplantation with interferon-α2b maintenance. The outcome was compared with 153 IgG and 39 IgA similarly treated myeloma patients. Response to IC and high-dose was comparable between the three subtypes but a significantly higher proportion of patients with… CONTINUE READING

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