Corpus ID: 37117453

Comparison of new nitrosoureas esters with modified steroidal nucleus for cytogenetic and antineoplastic activity.

@article{Hussein2007ComparisonON,
  title={Comparison of new nitrosoureas esters with modified steroidal nucleus for cytogenetic and antineoplastic activity.},
  author={A. Hussein and E. Mioglou-Kalouptsi and A. Papageorgiou and I. Karapidaki and Z. Iakovidou-Kritsi and T. Lialiaris and E. Xrysogelou and C. Camoutsis and D. Mourelatos},
  journal={In vivo},
  year={2007},
  volume={21 2},
  pages={
          389-95
        }
}
Nitrosourea is decomposed under physiological conditions to react with biological macromolecules by two mechanisms: alkylation (with proteins and nucleic acids) and carbamoylation (with proteins but not nucleic acids). It has been suggested that the alkylating action is responsible for the therapeutic effects of nitrosoureas, and that the carbamoylation activity leads to toxicity effects. In order to reduce systemic toxicity and improve specificity and distribution for cancer therapy, 2… Expand
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8 Citations
Background Citations
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Methods Citations
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8 Citations

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Citation Type

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Sister chromatid exchange assay as a predictor of tumor chemoresponse.
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Quantification of DNA interstrand crosslinks induced by ACNU in NIH/3T3 and L1210 cells using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry.
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In vitro and in vivo Cytogenetic Effects of Recombinant Human Erythropoietin on the Frequency of Sister Chromatid Exchanges Alone or in Combination with Mitomycin C
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Quantification of meCCNU-induced dG-dC crosslinks in oligonucleotide duplexes by liquid chromatography/electrospray ionization tandem mass spectrometry.
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