Comparison of neurotrophin and repellent sensitivities of early embryonic geniculate and trigeminal axons.

@article{Rochlin2000ComparisonON,
  title={Comparison of neurotrophin and repellent sensitivities of early embryonic geniculate and trigeminal axons.},
  author={Michael William Rochlin and R O'connor and Roman J Giger and Joost Verhaagen and Albert I. Farbman},
  journal={The Journal of comparative neurology},
  year={2000},
  volume={422 4},
  pages={579-93}
}
Geniculate (gustatory) and trigeminal (somatosensory) afferents take different routes to the tongue during rat embryonic development. To learn more about the mechanisms controlling neurite outgrowth and axon guidance, we are studying the roles of diffusible factors. We previously profiled the in vitro sensitivity of trigeminal axons to neurotrophins and target-derived diffusible factors and now report on these properties for geniculate axons. GDNF, BDNF, and NT-4, but not NT-3 or NGF, stimulate… CONTINUE READING

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