Comparison of neuropathic pain and neuronal apoptosis following nerve root or spinal nerve compression

  title={Comparison of neuropathic pain and neuronal apoptosis following nerve root or spinal nerve compression},
  author={Miho Sekiguchi and Yasufumi Sekiguchi and Shin-ichi Konno and Hideo Kobayashi and Yoshimi Homma and Shin-ichi Kikuchi},
  booktitle={European Spine Journal},
Altered dorsal root ganglion (DRG) function is associated with neuropathic pain following spinal nerve injury. However, compression of the cauda equina and dorsal rhizotomy proximal to the DRG do not induce significant pain, whereas in the spinal nerve and peripheral nerve, injury distal to the DRG does induce neuropathic pain. Caspase signaling induces apoptosis, and caspase inhibitors prevent pain-related behavior. The degree of DRG neuronal apoptosis is thought to play a role in pain… CONTINUE READING
37 Citations
46 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 37 extracted citations


Publications referenced by this paper.
Showing 1-10 of 46 references

The effect of site and type of nerve injury on spinal glial activation and neuropathic pain

  • RW Colburn, AJ Richman, JA DeLeo
  • behavior. Exp Neurol 157:289–304
  • 1999
Highly Influential
3 Excerpts

: Postnatal onset of mechanical allodynia in rat sprea nerve injury ( SNI ) and chronic constriction injury ( CCI ) models

  • S Hatashita, M Sekiguchi, H Kobayashi, S Konno, S Kikuchi
  • 2008

Fibro - nection / integrin system is involved in P 2 X 4 receptor upregulation in the spinal cord and neuropathic

  • M Tsuda, E Toyomitsu, +7 authors K Inoue
  • PAIN
  • 2008

Similar Papers

Loading similar papers…