Comparison of neuropathic pain and neuronal apoptosis following nerve root or spinal nerve compression

@inproceedings{Sekiguchi2009ComparisonON,
  title={Comparison of neuropathic pain and neuronal apoptosis following nerve root or spinal nerve compression},
  author={Miho Sekiguchi and Yasufumi Sekiguchi and Shin-ichi Konno and Hideo Kobayashi and Yoshimi Homma and Shin-ichi Kikuchi},
  booktitle={European Spine Journal},
  year={2009}
}
Altered dorsal root ganglion (DRG) function is associated with neuropathic pain following spinal nerve injury. However, compression of the cauda equina and dorsal rhizotomy proximal to the DRG do not induce significant pain, whereas in the spinal nerve and peripheral nerve, injury distal to the DRG does induce neuropathic pain. Caspase signaling induces apoptosis, and caspase inhibitors prevent pain-related behavior. The degree of DRG neuronal apoptosis is thought to play a role in pain… CONTINUE READING
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