Comparison of nephelometric, UV-spectroscopic, and HPLC methods for high-throughput determination of aqueous drug solubility in microtiter plates.

@article{Hoelke2009ComparisonON,
  title={Comparison of nephelometric, UV-spectroscopic, and HPLC methods for high-throughput determination of aqueous drug solubility in microtiter plates.},
  author={Bettina Hoelke and Sabine Gieringer and M. Arlt and Christoph Saal},
  journal={Analytical chemistry},
  year={2009},
  volume={81 8},
  pages={3165-72}
}
High-throughput screening (HTS) is an important method in the pharmaceutical industry for discovering hits that will be further developed into leads, clinical candidates, and eventually into medicines. After an HTS campaign, solubility studies of the discovered hits are an important means to judge the validity of the pharmacological result and to prioritize them for further studies. In the present paper, different methods for determination of kinetic solubility were compared that are able to… CONTINUE READING

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