Comparison of native, alkylated and charged cyclodextrins for the chiral separation of labetalol stereoisomers by capillary electrophoresis

@inproceedings{Potier1998ComparisonON,
  title={Comparison of native, alkylated and charged cyclodextrins for the chiral separation of labetalol stereoisomers by capillary electrophoresis},
  author={Isabelle le Potier and Sara L. Tamisier-Karolak and Ph. Morin and F. Megel and Myriam Taverna},
  year={1998}
}
A capillary electrophoresis method for the enantioresolution of labetalol was developed using CDs as chiral selectors and uncoated capillaries. Various native (α-, β- and γ-CD), alkylated (hydroxy propyl-β- and γ-CD, methyl-β-CD) and anionic (sulfated-β-CD and sulfobutylether-γ-CD) cyclodextrins were tested and operational parameters such as buffer pH, concentration of CD were investigated. Propranolol was also studied as a model compound. Uncharged γ-CDs were more effective than β-CDs to… CONTINUE READING