Comparison of myoplasmic calcium movements during excitation–contraction coupling in frog twitch and mouse fast-twitch muscle fibers

@inproceedings{Hollingworth2013ComparisonOM,
  title={Comparison of myoplasmic calcium movements during excitation–contraction coupling in frog twitch and mouse fast-twitch muscle fibers},
  author={Stephen Hollingworth and Stephen M Baylor},
  booktitle={The Journal of general physiology},
  year={2013}
}
Single twitch fibers from frog leg muscles were isolated by dissection and micro-injected with furaptra, a rapidly responding fluorescent Ca(2+) indicator. Indicator resting fluorescence (FR) and the change evoked by an action potential (ΔF) were measured at long sarcomere length (16°C); ΔF/FR was scaled to units of ΔfCaD, the change in fraction of the indicator in the Ca(2+)-bound form. ΔfCaD was simulated with a multicompartment model of the underlying myoplasmic Ca(2+) movements, and the… CONTINUE READING
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