Comparison of mu-, delta- and kappa-receptor binding sites through pharmacologic evaluation of p-nitrophenylalanine analogs of opioid peptides.

@article{Schiller1983ComparisonOM,
  title={Comparison of mu-, delta- and kappa-receptor binding sites through pharmacologic evaluation of p-nitrophenylalanine analogs of opioid peptides.},
  author={Peter W. Schiller and Thi M. -D Nguyen and John DiMaio and Carole Lemieux},
  journal={Life sciences},
  year={1983},
  volume={33 Suppl 1},
  pages={
          319-22
        }
}
For the purpose of comparing the structural requirements of opioid receptor subsites interacting with phenylalanine residues of opioid peptides, analogs containing p-nitrophenylalanine (Phe(pNO2) ) were synthesized and tested in the guinea pig ileum (GPI) and mouse vas deferens (MVD) assay as well as in mu- and delta-receptor selective binding assays. Whereas substitution of Phe(pNO2) in position 4 of the mu-selective analog H-Tyr-c[-N epsilon-D-Lys-Gly-Phe-Leu-] and of the delta-selective… CONTINUE READING