Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment.

@article{Genter2006ComparisonOM,
  title={Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment.},
  author={Mary Beth Genter and Corey D. Clay and Timothy P. Dalton and Hongbin Dong and Daniel W. Nebert and Howard G. Shertzer},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={342 4},
  pages={1375-81}
}
TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) induces cytochromes P450 (CYPs) such as CYP1A1 and CYP1A2 via activation of the aromatic hydrocarbon receptor (AHR). Herein we describe the TCDD-dependent enrichment of CYPs in liver microsomes and mitoplasts from C57BL/6J mice. TCDD-induced accumulation of CYP1A1 and CYP1A2 was observed in microsomes and mitoplasts after treatment with 15 microg TCDD/kg/d for 3d. While microsomal CYP1 proteins peaked at 1 week and diminished thereafter, mitoplast CYP1… CONTINUE READING