Comparison of microemulsion and conventional formulations of cyclosporine A in preventing acute rejection in de novo kidney transplant patients. The U.K. Neoral Renal Study Group.

@article{Pollard1999ComparisonOM,
  title={Comparison of microemulsion and conventional formulations of cyclosporine A in preventing acute rejection in de novo kidney transplant patients. The U.K. Neoral Renal Study Group.},
  author={Stephen G. Pollard and Paul A. Lear and Andrew R. Ready and Richard H. Moore and Robert Wood Johnson},
  journal={Transplantation},
  year={1999},
  volume={68 9},
  pages={1325-31}
}
BACKGROUND The microemulsion preconcentrate formulation of cyclosporine A (CsA) (Neoral) exhibits more uniform pharmacokinetics than the conventional formulation (Sandimmun; SIM). This randomized, open-label, U.K. multicenter study compared the efficacy, safety, and tolerability of Neoral and SIM in preventing acute rejection in de novo renal transplant recipients. METHODS Adult cadaveric kidney recipients (n=293) received Neoral or SIM twice daily for 12 months. Initially identical Neoral… CONTINUE READING
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