Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits

@inproceedings{Evans2018ComparisonOM,
  title={Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits},
  author={Luke M Evans and Rasool Tahmasbi and Scott Vrieze and Gonçalo R. Abecasis and Sayantan Das and Steven Gazal and Douglas W. Bjelland and Teresa R de Candia and M. E. Goddard and Benjamin M. Neale and Jian Yang and Peter M. Visscher and Matthew C. Keller},
  booktitle={Nature Genetics},
  year={2018}
}
Multiple methods have been developed to estimate narrow-sense heritability, h2, using single nucleotide polymorphisms (SNPs) in unrelated individuals. However, a comprehensive evaluation of these methods has not yet been performed, leading to confusion and discrepancy in the literature. We present the most thorough and realistic comparison of these methods to date. We used thousands of real whole-genome sequences to simulate phenotypes under varying genetic architectures and confounding… CONTINUE READING
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