Comparison of methods for evaluating drug-drug interaction.

  title={Comparison of methods for evaluating drug-drug interaction.},
  author={Liang Zhao and Jessie L-S Au and M. Guillaume Wientjes},
  journal={Frontiers in bioscience},
The goal of the present report is to compare several published methods of analyzing drug-drug interaction data. The compared methods are the curve-shift analysis, isobologram, combination index, and universal surface response analysis, and the comparison was based on analysis of published cytotoxicity data of combinations of two anti-folate agents. Major findings are as follows. The curve shift analysis enabled the inspection of the experimental data and visual evaluation of the approximate… CONTINUE READING