Comparison of meta-analytic results of indirect, direct, and combined comparisons of drugs for chronic insomnia in adults: a case study.

@article{Vandermeer2007ComparisonOM,
  title={Comparison of meta-analytic results of indirect, direct, and combined comparisons of drugs for chronic insomnia in adults: a case study.},
  author={Ben W Vandermeer and Nina Buscemi and Yuanyuan Liang and Manisha Witmans},
  journal={Medical care},
  year={2007},
  volume={45 10 Supl 2},
  pages={S166-72}
}
BACKGROUND Our Center recently conducted a systematic review of the manifestations and management of chronic insomnia in adults. The efficacy and safety of benzodiazepines and nonbenzodiazepines, relative to placebo, were compared indirectly. OBJECTIVES Determine how the results of indirect comparisons made in the review compare with the results of direct comparisons, as well as with estimates derived from Bayesian mixed treatment comparisons. Establish general appropriateness of the use of… CONTINUE READING

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