Comparison of mesocorticolimbic neuronal responses during cocaine and heroin self-administration in freely moving rats.

@article{Chang1998ComparisonOM,
  title={Comparison of mesocorticolimbic neuronal responses during cocaine and heroin self-administration in freely moving rats.},
  author={J Y Chang and Patricia H Janak and D. J. Woodward},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 8},
  pages={3098-115}
}
To compare neuronal activity within the mesocorticolimbic circuit during the self-administration of cocaine and heroin, multiple-channel single-unit recordings of spike activity within the rat medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) were obtained during the consecutive self-administration of cocaine and heroin within the same session. The variety of neuronal responses observed before the lever press are termed anticipatory responses, and those observed after the lever press… CONTINUE READING