Comparison of meningococcal outer membrane protein vaccines solubilized with detergent or C polysaccharide

@article{Poolman1987ComparisonOM,
  title={Comparison of meningococcal outer membrane protein vaccines solubilized with detergent or C polysaccharide},
  author={Jan T. Poolman and Hans A. M. Timmermans and Carla Th P Hopman and Tom Teerlink and P. A. M. Van Vught and M. H. Witvliet and E. Coen Beuvery},
  journal={Antonie van Leeuwenhoek},
  year={1987},
  volume={53},
  pages={413-419}
}
Outer membrane proteins (OMPs) were isolated from meningococcal strain H44/76 (B:15:P1.16) by detergent extraction of bacteria. A final product containing class 1 (P1.16), 3(15), 4 OMPs and 5% (w/w) lipooligosaccharide was obtained. Two experimental vaccines were prepared: OMP-detergent and OMP-C polysaccharide. The OMP-detergent vaccine tended to show a better bactericidal: ELISA ratio for the antibodies induced as compared to the OMP-C polysaccharide vaccine. The vaccine induced bactericidal… CONTINUE READING

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