Comparison of mass spectrometric analysis and TRUGENE HBV genotyping for monitoring lamivudine resistance in chronic hepatitis B patients.

@article{Woo2007ComparisonOM,
  title={Comparison of mass spectrometric analysis and TRUGENE HBV genotyping for monitoring lamivudine resistance in chronic hepatitis B patients.},
  author={Hee-Yeon Woo and Hyosoon Park and Byung-Ik Kim and Woo-Kyu Jeon and Yong Kyun Cho and Young Jae Kim},
  journal={Antiviral therapy},
  year={2007},
  volume={12 1},
  pages={7-13}
}
BACKGROUND There is an increasing need for the early detection of emerging mutations in the tyrosine-methionine-aspartate-aspartate (YMDD) motif of hepatitis B virus (HBV) DNA polymerase with using sensitive molecular methods. METHODS We evaluated the usefulness of monitoring lamivudine resistance using a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry-based assay (the restriction fragment mass polymorphism; RFMP) in comparison with the direct sequencing assay… CONTINUE READING