Comparison of mannitol and hypertonic saline in the treatment of severe brain injuries.

@article{Sakellaridis2011ComparisonOM,
  title={Comparison of mannitol and hypertonic saline in the treatment of severe brain injuries.},
  author={Nikolaos F. Sakellaridis and Elias Pavlou and Stylianos P Karatzas and Despina Chroni and Konstantinos Vlachos and Konstantinos Chatzopoulos and Eleni Dimopoulou and Christos Kelesis and Vasiliki Karaouli},
  journal={Journal of neurosurgery},
  year={2011},
  volume={114 2},
  pages={
          545-8
        }
}
OBJECT The purpose of this study was to compare the effects of mannitol and hypertonic saline in doses of similar osmotic burden for the treatment of intracranial hypertension in patients with severe traumatic brain injury. METHODS The authors used an alternating treatment protocol to compare the effect of hypertonic saline with that of mannitol given for episodes of increased intracranial pressure in patients treated for severe head injury at their hospital during 2006-2008. Standard… CONTINUE READING
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