Comparison of long-term outcome of children with severe aplastic anemia treated with immunosuppression versus bone marrow transplantation.

@article{Gillio1997ComparisonOL,
  title={Comparison of long-term outcome of children with severe aplastic anemia treated with immunosuppression versus bone marrow transplantation.},
  author={Alfred P. Gillio and Farid Boulad and Trudy N. Small and Nancy A Kernan and B. Reyes and Barrett H. Childs and Joel A Brochstein and Joseph Laver and Hugo R Castro-Malaspina and Richard J O'reilly},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={1997},
  volume={3 1},
  pages={18-24}
}
Children with severe aplastic anemia (SAA) are treated with bone marrow transplantation (BMT) if a human leukocyte antigen (HLA) compatible sibling donor is available, or alternatively with immunosuppressive therapy (IST). Three retrospective trials examining BMT vs IST in pediatric patients treated from 1970-1988 found BMT resulted in a superior survival rate. Advances have been made in general supportive care and in the approach to each of these treatment modalities in the last decade. To… CONTINUE READING