Comparison of long-term immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine in healthy women aged 18-45 years: End-of-study analysis of a Phase III randomized trial

@inproceedings{Einstein2014ComparisonOL,
  title={Comparison of long-term immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine in healthy women aged 18-45 years: End-of-study analysis of a Phase III randomized trial},
  author={M Heather Einstein and P{\'e}ter Tak{\'a}cs and Archana Chatterjee and R. S. Sherwin'R. S. Spangler'M. A. Sperling and Nahida A Chakhtoura and Mark M Blatter and Jacob P. Lalezari and M D{\'a}vid and Lan Lin and Frank Struyf and Gary O. Dubin},
  booktitle={Human vaccines & immunotherapeutics},
  year={2014}
}
The observer-blind, randomized, age-stratified, head-to-head study (NCT00423046) comparing immunogenicity and safety of HPV-16/18 and HPV-6/11/16/18 vaccines in healthy women aged 18-45 y was completed. Five y after vaccination, in subjects from the Month 60 according-to-protocol cohort (seronegative and DNA negative for HPV type analyzed at baseline), serum neutralizing antibody (nAb) responses induced by HPV-16/18 vaccine remained 7.8-fold (18-26-y stratum), 5.6-fold (27-35-y stratum) and 2.3… CONTINUE READING
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