Comparison of llama VH sequences from conventional and heavy chain antibodies.

@article{Vu1997ComparisonOL,
  title={Comparison of llama VH sequences from conventional and heavy chain antibodies.},
  author={Khang Vu and Mehdi Arbabi Ghahroudi and Lode Wyns and Serge Muyldermans},
  journal={Molecular immunology},
  year={1997},
  volume={34 16-17},
  pages={1121-31}
}
Forty different PCR clones encoding a llama variable heavy chain domain were analysed. The majority of these clones are derived from heavy-chain antibody cDNA in which the entire CH1 exon is absent. It appears from the amino acid within the VHH framework 1 and 3 that all the llama clones belong to the VH III family. However, the individual llama VHH sequences differ more substantially from each other than expected for members of the same family. Several remarkable amino acid substitutions in… CONTINUE READING
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