Comparison of liquid chromatography with tandem mass spectrometry and ion-exchange chromatography by post-column ninhydrin derivatization for amino acid monitoring.

@article{mon2019ComparisonOL,
  title={Comparison of liquid chromatography with tandem mass spectrometry and ion-exchange chromatography by post-column ninhydrin derivatization for amino acid monitoring.},
  author={Andra{\vz} {\vS}mon and V Vladimir Cuk and Jernej Brecelj and Simona Murko and Urh Gro{\vs}elj and Mojca Zerjav Tansek and Tadej Battelino and Barbka Repic Lampret},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2019},
  volume={495},
  pages={
          446-450
        }
}
OBJECTIVES Precise quantification of amino acids (AAs) is mandatory for successful diagnosis and monitoring of patients with metabolic diseases. We compared ion-exchange chromatography (IEC) and liquid chromatography with tandem mass spectrometry (LC-MS/MS), the two methods most commonly used in clinical laboratories for the quantification of AAs in physiological samples. DESIGN & METHODS 123 apparently healthy children were selected for the study. The plasma samples for LC-MS/MS were… CONTINUE READING
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