Comparison of liquid chromatography, capillary electrophoresis and super-critical fluid chromatography in the determination of Losartan Potassium drug substance in Cozaar tablets.

Abstract

Reversed phase liquid chromatography, micellar electrokinetic chromatography, and packed column supercritical fluid chromatography were used to measure the amount of Losartan Potassium drug substance in pharmaceutical tablets. Tablet extract samples were analyzed and results were used to compare accuracy, precision, and linearity of calibration of the instrumental techniques. All three techniques have satisfactory precision (less than 1% RSD) and accuracy to be used for the analysis of the drug substance in tablets and the advantages of each technique are discussed.

Cite this paper

@article{Williams1996ComparisonOL, title={Comparison of liquid chromatography, capillary electrophoresis and super-critical fluid chromatography in the determination of Losartan Potassium drug substance in Cozaar tablets.}, author={Ross C. Williams and Mark S Alasandro and Vincenzo Fasone and R J Boucher and James Frederick Edwards}, journal={Journal of pharmaceutical and biomedical analysis}, year={1996}, volume={14 11}, pages={1539-46} }