Comparison of line‐field confocal optical coherence tomography images with histological sections: Validation of a new method for in vivo and non‐invasive quantification of superficial dermis thickness

  title={Comparison of line‐field confocal optical coherence tomography images with histological sections: Validation of a new method for in vivo and non‐invasive quantification of superficial dermis thickness},
  author={M{\'e}lanie Pedrazzani and Josselin Breugnot and Pauline Rouaud-Tinguely and Maxime Cazalas and Arthur J. Davis and Sylvie Bordes and Arnaud Dubois and Brigitte Closs},
  journal={Skin Research and Technology},
  pages={398 - 404}
Line‐field confocal optical coherence tomography (LC‐OCT) is an imaging technique providing “optical biopsies” of the skin in real time and non‐invasively. At a center optical wavelength of 1.3 µm, this innovative technology can be applied to dermo‐cosmetic product development due to both high image resolution (~2 µm) and sufficient penetration (~0.5 mm). Nevertheless, the precise dermal area analyzed with LC‐OCT has never been identified. In this study, the objective was to compare LC‐OCT… 
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  • Medicine
    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging
  • 2020
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Validation of optical coherence tomography in vivo using cryostat histology.
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  • Medicine
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OCT research in dermatology has undergone significant developments since its first application in 1997 and the rising demand for non-invasive monitoring of skin disorders and treatment outcomes emphasize the need for further advances in the field of non- invasive imaging.
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  • 2017
In addition to dermoscopy, there are other imaging and biophysical methods for the noninvasive diagnosis of skin lesions and these methods are used in the differentiation of dysplastic nevi from melanoma.
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Simultaneous dual-band line-field confocal optical coherence tomography: application to skin imaging.
Line-field confocal optical coherence tomography (LC-OCT) operating in two distinct spectral bands centered at 770 nm and 1250 nm is reported, using a single supercontinuum light source and two