Comparison of lidocaine, metoclopramide, and flurbiprofen axetil for reducing pain on injection of propofol in Japanese adult surgical patients: a prospective, randomized, double-blind, parallel-group, placebo-controlled study.

@article{Fujii2008ComparisonOL,
  title={Comparison of lidocaine, metoclopramide, and flurbiprofen axetil for reducing pain on injection of propofol in Japanese adult surgical patients: a prospective, randomized, double-blind, parallel-group, placebo-controlled study.},
  author={Yoshitaka Fujii and Michiyo Itakura},
  journal={Clinical therapeutics},
  year={2008},
  volume={30 2},
  pages={
          280-6
        }
}
BACKGROUND Pain on injection is a recognized adverse event (AE) of propofol administration for the induction of general anesthesia. Pretreatment with lidocaine, metoclopramide, or flurbiprofen axetil has been reported to be effective in reducing propofol-induced pain. However, no studies comparing the efficacy of these 3 drugs for preventing pain on injection of propofol have been identified. OBJECTIVE The aim of this study was to compare the efficacy of lidocaine, metoclopramide, and… CONTINUE READING
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