Comparison of leukotriene A4 metabolism into leukotriene C4 by human platelets and endothelial cells.

@article{Habib1992ComparisonOL,
  title={Comparison of leukotriene A4 metabolism into leukotriene C4 by human platelets and endothelial cells.},
  author={Aida Habib and Jacques Maclouf},
  journal={Archives of biochemistry and biophysics},
  year={1992},
  volume={298 2},
  pages={544-52}
}
Leukotriene (LT) A4 metabolism was studied in human platelets and endothelial cells, since both cells could be involved in transcellular formation of LTC4. Upon addition of exogenous LTA4, both cells produced LTC4 as a major metabolite at various incubation times, and no LTB4, LTD4, or LTE4 was detected. Kinetic studies revealed a higher apparent Km for… CONTINUE READING