Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency

  title={Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency},
  author={Curt Diehm and Hans J Trampisch and Stefan Lange and C Schmidt},
  journal={The Lancet},
BACKGROUND Diseases of the venous system are widespread disorders sometimes associated with modern civilisation and are among the major concerns of social and occupational medicine. This study was carried out to compare the efficacy (oedema reduction) and safety of compression stockings class II and dried horse chestnut seed extract (HCSE, 50 mg aescin, twice daily). METHODS Equivalence of both therapies was examined in a novel hierarchical statistical design in 240 patients with chronic… 
Rational therapy of chronic venous insufficiency – chances and limits of the therapeutic use of horse-chestnut seeds extract
Due to its ability to close the venular endothelial gaps, HCSE seems to be a suitable and protecting therapy during the early stages of CVI, in later more severe stages compression therapy is indicated.
Horse chestnut seed extract for chronic venous insufficiency.
The evidence presented suggests that HCSE is an efficacious and safe short-term treatment for CVI, however, several caveats exist and larger, definitive RCTs are required to confirm the efficacy of this treatment option.
Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: A review of 5 clinical studies
Safe, well tolerated, and acceptable to patients, the fresh plant HCSE preparation Aesculaforce offers a real alternative in the treatment of patients with mild to moderate venous insufficiency.
orse chestnut – efficacy and safety in chronic venous insufficiency : n overview
The extract from horse chestnut seeds (Aesculus hippocastanum L., Sapindaceae), standardised for the content of aescin, is used as the treatment for chronic venous insufficiency. It has
Horse chestnut – efficacy and safety in chronic venous insufficiency: an overview
It is proven that horse chestnut seed extract not only significantly improves subjective symptoms in patients with chronic venous insufficiency like calf spasm, leg pain, pruritus, fatigue, but it also reduced leg volume, the ankle and calf circumference.
Horse chestnut:a multidisciplinary clinical review.
These studies support the superiority of HCSE over placebo, and suggest equivalence to compression stockings and to oral oxerutins, and these products not be used, as they are known to be toxic when ingested.
Long-term observational study on outpatient treatment of venous diseases with medical compression stockings in Germany
The data show that mediven® MCSs are very well tolerated and lead to a subjective improvement in symptoms, which clearly confirm the need to optimise provision to patients with venous disorders.
Daflon 500 mg and Venous Leg Ulcer: New Results From a Meta-Analysis
The results confirm that venous ulcer healing is accelerated by Daflon 500 mg treatment and might be a useful adjunct to conventional therapy in large and longstanding ulcers that might be expected to heal slowly.
Venous leg ulcer: a meta-analysis of adjunctive therapy with micronized purified flavonoid fraction.
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It is confirmed that venous ulcer healing is accelerated by MPFF treatment, and MPFF might be a useful adjunct to conventional therapy in large and long standing ulcers.
Effectiveness and safety of calcium dobesilate in treating chronic venous insufficiency: randomized, double-blind, placebo-controlled trial
In contrast with the placebo, the effects of CaD were independent of the duration of CVI and most pronounced in more severely diseased patients, suggesting that CaD is an effective and well tolerated treatment for chronic venous insufficiency.


Compression therapy of the legs. A review.
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Compression therapy is a powerful method for the treatment of all sorts of swollen extremities. Its effects depend on several factors, including: underlying disease, exerted pressure and body
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It is shown that to the extent that active control equivalence studies are successful the results of such trials must raise doubts regarding their competence, and ACES are thus more problematic than classical clinical trials.
Mucosal and enterocyte grafts in the intestine