Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency

@article{Diehm1996ComparisonOL,
  title={Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency},
  author={Curt Diehm and Hans J Trampisch and Stefan Lange and C Schmidt},
  journal={The Lancet},
  year={1996},
  volume={347},
  pages={292-294}
}
BACKGROUND Diseases of the venous system are widespread disorders sometimes associated with modern civilisation and are among the major concerns of social and occupational medicine. This study was carried out to compare the efficacy (oedema reduction) and safety of compression stockings class II and dried horse chestnut seed extract (HCSE, 50 mg aescin, twice daily). METHODS Equivalence of both therapies was examined in a novel hierarchical statistical design in 240 patients with chronic… 
Rational therapy of chronic venous insufficiency – chances and limits of the therapeutic use of horse-chestnut seeds extract
TLDR
Due to its ability to close the venular endothelial gaps, HCSE seems to be a suitable and protecting therapy during the early stages of CVI, in later more severe stages compression therapy is indicated.
Horse chestnut seed extract for chronic venous insufficiency.
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The evidence presented suggests that HCSE is an efficacious and safe short-term treatment for CVI, however, several caveats exist and larger, definitive RCTs are required to confirm the efficacy of this treatment option.
Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: A review of 5 clinical studies
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Safe, well tolerated, and acceptable to patients, the fresh plant HCSE preparation Aesculaforce offers a real alternative in the treatment of patients with mild to moderate venous insufficiency.
orse chestnut – efficacy and safety in chronic venous insufficiency : n overview
The extract from horse chestnut seeds (Aesculus hippocastanum L., Sapindaceae), standardised for the content of aescin, is used as the treatment for chronic venous insufficiency. It has
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It is proven that horse chestnut seed extract not only significantly improves subjective symptoms in patients with chronic venous insufficiency like calf spasm, leg pain, pruritus, fatigue, but it also reduced leg volume, the ankle and calf circumference.
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These studies support the superiority of HCSE over placebo, and suggest equivalence to compression stockings and to oral oxerutins, and these products not be used, as they are known to be toxic when ingested.
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The results confirm that venous ulcer healing is accelerated by Daflon 500 mg treatment and might be a useful adjunct to conventional therapy in large and longstanding ulcers that might be expected to heal slowly.
Venous leg ulcer: a meta-analysis of adjunctive therapy with micronized purified flavonoid fraction.
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In contrast with the placebo, the effects of CaD were independent of the duration of CVI and most pronounced in more severely diseased patients, suggesting that CaD is an effective and well tolerated treatment for chronic venous insufficiency.
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