Comparison of lead bioavailability in F344 rats fed lead acetate, lead oxide, lead sulfide, or lead ore concentrate from Skagway, Alaska.

@article{Dieter1993ComparisonOL,
  title={Comparison of lead bioavailability in F344 rats fed lead acetate, lead oxide, lead sulfide, or lead ore concentrate from Skagway, Alaska.},
  author={Michael P. Dieter and Hilary Matthews and R A Jeffcoat and R F Moseman},
  journal={Journal of toxicology and environmental health},
  year={1993},
  volume={39 1},
  pages={
          79-93
        }
}
An animal model using rats was developed to initiate investigations on the bioavailability of different sources of environmental lead. Lead must be absorbed and transported to target organs like brain, liver, kidney, and bone, before susceptible cells can be harmed. The bioavailability and therefore the toxicity of lead are dependent upon the route of exposure, dose, chemical structure, solubility, particle size, matrix incorporation, and other physiological and physicochemical factors. In the… CONTINUE READING
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