Comparison of kynurenic acid and 2-APV suppression of epileptiform activity in rat hippocampal slices.

@article{Stone1988ComparisonOK,
  title={Comparison of kynurenic acid and 2-APV suppression of epileptiform activity in rat hippocampal slices.},
  author={Trevor W Stone},
  journal={Neuroscience letters},
  year={1988},
  volume={84 2},
  pages={234-8}
}
The N-methyl-D-aspartate (NMDA) receptor blocker 2-amino-5-phosphonovaleric acid [+/-)-2-APV) and kynurenic acid both suppressed spontaneous epileptiform burst discharges in the CA3 region of rat hippocampal slices. When the bursts were induced by perfusion with magnesium-free medium (+/-)-2-APV was the more potent inhibitor (ED50 66 microM for (+/-)-2-APV and 110 microM for kynurenate). When bursts were induced by picrotoxin, kynurenate was more potent with an ED50 of 132 microM, compared with… CONTINUE READING