Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium.

@article{Zhou2008ComparisonOK,
  title={Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium.},
  author={Yuzhao Zhou and Vishal S. Vaidya and Ronald P Brown and Jun Zhang and Barry A. Rosenzweig and Karol L. Thompson and Terry J Miller and Joseph V. Bonventre and Peter L. Goering},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2008},
  volume={101 1},
  pages={159-70}
}
Sensitive biomarkers are needed to detect kidney injury at the earliest stages. The objective of this study was to determine whether the appearance of kidney injury molecule-1 (Kim-1) protein ectodomain in urine and kidney injury molecule-1/hepatitis A viral cellular receptor-1 (Kim-1/Havcr1) gene expression in kidney tissue may be more predictive of renal injury after exposure to nephrotoxicants when compared to traditionally used biomarkers. Male Sprague-Dawley rats were injected with a range… CONTINUE READING
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A microfluidics based assay to measure kidney injury molecule-1 (Kim-1) in the urine as a biomarker for early diagnosis of acute kidney injury

  • V. S. Vaidya, V. Ramirez, N. A. Bobadilla, J. V. Bonventre
  • J. Am. Soc. Nephrol
  • 2005
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