Comparison of irbesartan with captopril effects on cardiac hypertrophy and gene expression in heart failure-prone male SHHF/Mcc-fa(cp) rats.

@article{Carraway1999ComparisonOI,
  title={Comparison of irbesartan with captopril effects on cardiac hypertrophy and gene expression in heart failure-prone male SHHF/Mcc-fa(cp) rats.},
  author={J W Carraway and S Park and Sylvia A. McCune and Bethany J. Holycross and M J Radin},
  journal={Journal of cardiovascular pharmacology},
  year={1999},
  volume={33 3},
  pages={451-60}
}
Angiotensin-converting enzyme (ACE) inhibitors have proven an effective means to control hypertension and manage cardiac hypertrophy. It is presently unknown if newer specific angiotensin II subtype 1 receptor (AT1R) antagonists are as effective or more effective in treating these conditions compared with ACE inhibitors. There is evidence that these classes of drugs may affect cardiac hypertrophy by different mechanisms. This study compared the effect of irbesartan, an AT1R antagonist, with… CONTINUE READING

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