Comparison of insulin secretory function in two mouse models with different susceptibility to beta-cell failure.

@article{Kooptiwut2002ComparisonOI,
  title={Comparison of insulin secretory function in two mouse models with different susceptibility to beta-cell failure.},
  author={Suwattanee Kooptiwut and Sakeneh Zraika and A. W. Thorburn and Marjorie E. Dunlop and Rima Darwiche and Thomas W.H Kay and J. Proietto and Sofianos Andrikopoulos},
  journal={Endocrinology},
  year={2002},
  volume={143 6},
  pages={2085-92}
}
Type 2 diabetes is characterized by a susceptibility to beta-cell failure. However, subjects at risk of developing type 2 diabetes, such as those with obesity or a family history of diabetes, have been shown to display hyperinsulinemia. Although this hyperinsulinemia may be an adaptive response to insulin resistance, the possibility that insulin hypersecretion may be a primary defect has not been thoroughly investigated. The DBA/2 mouse is a model of pancreatic islet susceptibility. Unlike the… CONTINUE READING