Comparison of insulin regimens in patients with non-insulin-dependent diabetes mellitus.

@article{YkiJrvinen1992ComparisonOI,
  title={Comparison of insulin regimens in patients with non-insulin-dependent diabetes mellitus.},
  author={Hannele Yki-J{\"a}rvinen and Marjut Kauppila and Erkki Kujansuu and Jari Lahti and T Marjanen and Leo Niskanen and Scott Rajala and L. Ryysy and Sakari Salo and Pekka Sepp{\"a}l{\"a}},
  journal={The New England journal of medicine},
  year={1992},
  volume={327 20},
  pages={1426-33}
}
BACKGROUND Insulin is widely used to improve metabolic control in patients with non-insulin-dependent diabetes mellitus (NIDDM), but there is no consensus about the optimal regimen of insulin treatment. METHODS We treated 153 patients with NIDDM for three months with five regimens: (1) oral hypoglycemic drug therapy plus NPH insulin given at 7 a.m. (the morning-NPH group), (2) oral hypoglycemic drug therapy plus NPH insulin given at 9 p.m. (the evening-NPH group), (3) NPH and regular insulin… CONTINUE READING

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